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Description
Aberrant histone methylation and acetylation, ATRX mutations impacting chromatin stability, and widespread promoter hypermethylation, including MGMT, disrupt the balance between tumor suppressor genes and oncogenic pathways
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DCA has been administered intravenously acutely and chronically by mouth or feeding tube to treat children with PDC deficiency or with one or more defects in nuclear DNA or mitochondrial DNA-encoded proteins of the respiratory chain complexes (Abdelmalak, et al., 2013
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Voehringer DW, Meyn RE
