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A phase II randomized blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy

Equally important, urinary acylcarnitine profiling provides complementary information to plasma analysis [151,152,153,154]

doi: 10.1016/S0040-4020(01)00773-6

Mendez, I

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Additionally, the loss of GlS1 leads to -kG deficiency, and impairs the differentiation of Th17 cells [84].Glutamine uptake transporters such as ASCT2, Solute carrier family 7, member 5 (SLC7A5) and Sodium-coupled Neutral Amino Acid Transporter (SNAT), when blocked, inhibit the differentiation of CD4 + Th1 and Th17 cells [83], while SLC7A5-mediated glutamine uptake regulates the activation of c-MYC-dependent Teff cells