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Energy Expenditure and Thermogenesis Research Research applications extend to metabolic rate investigation: Oxygen Consumption: Measurement of whole-body or tissue-specific respiration rates Mitochondrial Function: Studies on oxidative phosphorylation, ATP production, membrane potential Mitochondrial Biogenesis: Investigation of mitochondrial mass, mtDNA copy number, biogenesis gene expression Brown Adipose Tissue: Research on BAT activation, UCP1 expression, thermogenic capacity Physical Activity: Examination of spontaneous activity and exercise performance Substrate Oxidation: Studies on fatty acid vs

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There was also support for continuing to include these more comprehensively within the case mix weight, rather than adding additional metrics and further exploration of measures that assess quality of life for the beneficiary and the family caregiver in relation to chronic illness

The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo