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Wild-type and mutated IDH1/2 enzymes and therapy responses

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Furthermore, a randomized clinical trial from Beaumont et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Kim S.H., et al

Orchestrating endosomal cargo retrieval and recycling are several multi-protein assemblies that include sorting nexin-27 (SNX27)-Retromer and SNX3-Retromer 8,9,10,11,12,13,14,15,16 , SNX17-Retriever and associated Commander super-assembly 17,18,19,20,21,22 , the branched F-actin polymerising WASH complex and its regulatory MAGE-L2/USP7/TRIM27 (MUST) complex 23,24,25 , and the SNX-BAR proteins and endosomal sorting complex required for exit-1 (ESCPE-1) 26,27,28,29,30,31

Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified
