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As it has been previously mentioned, free radicals have been implicated as mediators on exercise-induced cellular dysfunction and cell to cell signalling

10.1038/ncomms11756 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Chiou J, Zeng C, Cheng Z et al (2021) Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

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The intranasal route could be a solution to poor oral absorption of neuroprotective compounds like quercetin, gallotannin and tetrandrine