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doi: 10.3389/fimmu.2026.1773284 Received 22 December 2025 Revised 13 February 2026 Accepted 05 March 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Sudhir Gupta, University of California, Irvine, United States Reviewed by Charlotte Slade, The University of Melbourne, Australia Anupriya Kaur, Post Graduate Institute of Medical Education and Research (PGIMER), India Updates Copyright 2026 Jans, Al, Bouman, Geelen, Kleefstra and Placek

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126 In a randomized controlled trial, 40 patients with tinnitus (17 of whom also had vitamin B12 deficiency with levels below 250 pg/mL) were treated with weekly intramuscular injections providing 2,500 mcg vitamin B12 or saline (placebo) for six weeks

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