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Oxidative stress is incurred by the increase of free radicals in the organism, while the eliminative ability of free radicals decreased at the same time

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In general, an earlier age of onset of bone disease is associated with a poorer prognosis [41]

10.1053/j.gastro.2015.07.003 127 SaraceniP

A complete list of signaling pathways regulated by ROS or RNS still awaits identification, the data presented in this review are therefore far from offering a comprehensive picture of the function of NO and ROS during plant PCD