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The therapeutic potential of melatonin and its novel synthetic analogs in circadian rhythm sleep disorders, inflammation-associated pathologies, and neurodegenerative diseases

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Retinal ganglion cells express TrkB making them responsive to BDNF signaling critical for survival especially during stress or injury

Interestingly, it has been shown that GSH levels tend to increase due to glutamate-mediated excitatory activity (Tebartz Van Elst et al., 2014), and one of the hypotheses related to symptoms of ASD is the presence of an imbalance between excitatory neurotransmitter, glutamate, and one of the principal inhibitory transmitter, GABA

These results indicated that RS could respond to intracellular GSH and transform into fibrous nanostructure in high GSH level B16 cells, which is consistent with the results of LCMS traces (Fig