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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis

Clinical strategies are actively addressing this limitation

To view a copy of this license, visit About this article Cite this article Knorr, S., Sinn, M., Galetskiy, D

Pulsatile GH signals also activate organ-specic second messenger signaling pathways, such as the Signal Transducer and Activator of Transcription 5B (stat5B) in the liver, with subsequent induction of specic genomic responses in relevant target tissues

Despite these advances, several mechanistic uncertainties remain

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