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Possible side effects include: Nausea, diarrhea, vomiting, constipation, mild to moderate abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, belching, hypoglycemia, flatulence, gastroenteritis, loss of lean muscle mass and gastroesophageal reflux disease

Biotin supplementation may also help to reduce flaking and irritation caused by topical retinoids