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In correlation to its biotransformation and detoxification ability, GSTP1 is expressed in most cells and particularly in those that are in contact with the external environment such as cells of the urinary, digestive, and respiratory tract (Terrier et al., 1990

An animal study showed that NAC increased histamine release in conjunction with fluoride.[ref] In people given IV n-acetylcysteine in a hospital setting for acetaminophen poisoning, about 8% of the patients had an anaphylactoid reaction, defined as cutaneous (urticaria, pruritus, angioedema) or systemic (hypotension, respiratory symptoms) within five hours of receiving the IV

doi: 10.1021/tx700185s

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Serums are light but concentrated, so they go deeper into the skin compared to a normal cream

A., & Herzenberg, L