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Furthermore, transport of GSH and/or GSH precursors via astrocytederived extracellular vesicles to neurons has been proposed as a process to supply neurons with GSH precursors (PrezSala and Pajares 2023)

doi: 10.3389/fphar.2026.1795174 Received 24 January 2026 Revised 09 April 2026 Accepted 13 April 2026 Published 30 April 2026 Volume 17 - 2026 Edited by Nabil Eid, IMU University, Malaysia Reviewed by MoezAlIslam Ezzat Faris, Applied Science Private University, Jordan Payal Bhatnagar, International Medical University, Malaysia Gehan El Akabawy, Ajman University, United Arab Emirates Updates Copyright 2026 Ma, Hao, Wang, Qiu, Cao, Deng, Wang, Li, Zhang, Wei, Yao, Gao, Yi, Liu and Li

BPC-157 doesn't interact with the receptors, pathways, or metabolic processes that drive GLP-1 mediated weight loss

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Its version without Drug Affinity Complex (DAC) typically has a shorter half-life measured in hours, while the DAC-modified version can remain active for several days because the modification slows degradation since the DAC component allows the peptide to bind to albumin in the bloodstream, extending circulation time