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It is important to keep in mind, however, that some of these substances may have pharmacological limitations, including the mechanism of drug action, administration route, tolerability, side effects, and proven efficacy, that should be considered before they could be approved for its use in this pathology

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Inflammation and cardiovascular disease: From mechanisms to therapeutics

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Subsequent research demonstrated that benzodiazepine and other chemical distinct PBR ligands were able to stimulate steroid biosynthesis by mobilizing mitochondrial cholesterol transport in isolated mitochondria, cell cultures, as well as in humans (108111), and based on work implying the involvement of this protein in mitochondrial cholesterol and heme tetrapyrrole import, the PBR was renamed the TSPO (112)

Accordingly, patients with AML were found to display an abnormal glucose metabolism signature, and several glucose metabolite biomarkers had been implicated as prognostic values [36]