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The clinical application of alpha-lipoic acid in metabolic dysfunction-associated steatotic liver disease Metabolic Dysfunction-associated Steatotic Liver Disease is a chronic liver disease characterized by excessive fat accumulation in the liver, insulin resistance, oxidative stress and inflammatory responses, which can progress to non-alcoholic steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma

In contrast, the intracellular ROS levels significantly increased 3 h after LP treatment and decreased to the control level after 24 h (Supplementary Fig

Another model to assess the relative importance of endocrine versus paracrine/autocrine IGF-I is the liver-specific Ghr ko mouse

[DOI] [PMC free article] [PubMed] [Google Scholar] Hellstrm F

As with any hormone-modulating therapy, treatment decisions should be individualized and based on a careful assessment of potential risks, expected benefits, medical history, and treatment goals

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