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treating on NAFLD may relate to alleviate oxidative stress, reduce lipid accumulation, anti-inflammation, and regulate gut microbiota disorders

Biomolecules 12 (6), 824

10.1016/j.neuroscience.2009.03.019 Neuroscience 25 GonzalezA.HydeE.SangwanN.GilbertJ

Folate plays a critical role in the remethylation of homocysteine, and hyper-homocysteinemia is known to promote endothelial dysfunction and vascular permeability

Green RS, Downing DT, Pochi PE, Strauss JS

Alternative approaches could be used to alter levels of apoE in the periphery via genetic interventions, or with the use of structural modifiers to modulate the function of peripheral apoE in an isoform-specific fashion as discussed in earlier sections