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The thiol group of cysteines reacts with a diverse array of molecules referred to as reactive oxygen, nitrogen, sulfur, or carbonyl species, generating various types of redox post-translational modifications (PTMs) (Couturier et al., 2013)

Etanercept, a human TNFR p75 Fc fusion protein produced using a Chinese hamster ovary cell expression system, competes with blood TNF for binding, thereby blocking its interaction with cell surface TNFR and reducing TNF activity

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doi: 10.1017/S0007114517003774

Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ

Petechial spots do not typically cause pain or itching