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The result of this immune reaction, which can result in minor inflammation, might provoke temporary headaches, particularly in the early phase of the accumulation of doses when the dosage is still rising

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They can cause adverse effects

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Funding The study was supported by the Henan Province Science and Technology Project (182102310112, ZY), the National S&T Major Project of China (2018ZX10301201-008), National Natural Science Foundation of China (81600506), National Key Research and Development Program of China (2018YFC2000501), and China Postdoctoral Science Foundation (2017464 and 20182814)