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doi: 10.1161/CIRCRESAHA.110.217117

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hence, overnutrition can lead to dysregulation of this process Autophagy influences energy metabolism both locally (tissue-specific effects) and globally (endocrine effects) Pharmacological modulation of autophagy could prove feasible for the prevention and treatment of metabolic disorders Abstract Knowledge gained over the past 10 years about the mechanisms that underpin autophagy has provided a universal framework for studies of diverse physiological and pathological processes

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Van den Bossche, J., ONeill, L