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Over a dozen landmark randomized controlled trials (RCTs) have been completed in the past 5 years, including the first head-to-head biologic trials, the first combination biologic studies, and multiple phase III registrational trials of novel compounds with new co-primary and composite end points that will change the treatment landscape for years to come

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Its inclusion in traditional diets reflects its importance as a source of essential nutrients, including vitamin B12

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Its antioxidant properties have proven effective in reducing the oxidative stress and tissue damage associated with IR injury [38,39,40]

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