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Otolaryngol Clin North Am 30(5):727743 Ross BG, Fradet G, Nedzelski JM (1996) Development of a sensitive clinical facial grading system
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Intranasal immunisation can prime both mucosal and systemic immunity, typically inducing secretory IgA at mucosal surfaces and circulating IgG, thereby providing layered protection (Kiyono and Fukuyama, 2004
The reason for this is they are already in their active forms, ready to be used by the body
If you missed a dose of it, take it as soon as you can but never take a double dose
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