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The genetic variable Variants in MTHFR , MTRR , COMT shape the baseline biology that MIC-B12 acts on

7 Although the role of folic acid supplementation in reducing homocysteine levels as a method for preventing coronary artery disease and stroke continues to be a subject of great interest, there has been little emphasis on the potential role of vitamin B 12 deficiency as a contributing factor in the development of cardiovascular disease

Magnesium can enhance the vasoactive effects of calcium-channel blockers, which may lead to a worsening hypotension