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Edgley for C

Compared to L-arginine, an advantage to supplementation with L-citrulline is that intestinal catabolism of L-citrulline is limited since it is not metabolized by arginases, and the activity of arginosuccinate synthase is low in enterocytes [2]

& Peterson, B

Journal of Neuroimmune Pharmacology 7 , 444453 (2012)

These psychological disturbances influence several biological mechanisms implicated in the progression of SCI (i.e., hyperactivation of the HPA axis), impairing the immune, endocrine and nervous systems