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Furthermore, by employing the MPTP mouse model to simulate mitochondrial damage and GSH deficiency in PD, we demonstrate that pyridoxine-induced GSH enhancement helpes to reduce the severity of dopaminergic neuron loss and improve some types of mouse locomotion after MPTP administration

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On the other hand, the wild-type strain could relieve the high NAD + usage by employing Gdh3 which is dependent on NADP +

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