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For high-risk patients, laparoscopy has proven to be safe and feasible and was also associated with decreased rates of mortality, postoperative morbidity, and shorter hospitalization [41]

Original draft preparation: AKu, NS

Concurrently, silybin regulates the degradation of HIF-1 by increasing the levels of prolyl hydroxylase PHD2 and reducing the interaction between HIF-1 and the VHL protein (89)

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