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Egger M, Juni P, Bartlett C: Value of flow diagrams in reports of randomized controlled trials
108 Additionally, XRCC3 oxidation affects its response to DNA damage, 109 indicating that the oxidation state may influence its role in oxidative stress versus DNA repair

Sirtuins are NAD+-dependent protein deacetylases, and seven sirtuin members can be involved (SIRT1SIRT7) (Grnewald et al., 2019

Blume CA, Boni CC, Casagrande DS, Rizzolli J, Padoin AV, Mottin CC

The first responding cells are microglia and adult oligodendrocyte precursor cells (OPC), which migrate towards the lesion, with astrocyte responses to follow

However, whether those delivering platforms caused topical/systemic toxicity or any long-term negative effects warrants continued research attention and effort
