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Since ongoing low-level inflammation contributes to aging (it can degrade collagen and lead to blotchiness), using peptides can help calm the skins environment for a more even-toned, less reactive complexion

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Increased ROS, in turn, upregulates expression of hypoxia inducible factor-1 (HIF-1) which stabilizes expression of BACE1 as well as increases the activity of PDK1, thereby reducing PDH activity and reducing mitochondrial pyruvate flux through oxidative phosphorylation [203]

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