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Support for DNA alkylation by cyclopropane ring opening

In this study, we utilized the small molecule PFK15, a competitive inhibitor of the rate limiting glycolysis enzyme 6-phosphofructo-2-kinase/fructose-2,6- biphosphatase 3 (PFKFB3)

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37,38 In 1998, we first described the unique ability of the D4R to carry out folate-dependent methylation of membrane phospholipids, utilizing a conformationally active methionine residue at the inner membrane surface