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Alkaline environments accelerate the polymerization and favor the formation of semiquinone radicals (Souza et al., 2025), whereas acidic solutions tend to inhibit dopamine oxidation and reduce ROS formation (Lv et al., 2025)

A scoping review of Pacing for management of myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS): lessons learned for the long COVID pandemic

In the US, landmark initiatives such as the Orphan Drug Act (1983) 26 and the Accelerating Rare disease Cures program (2022) have promoted this mission by driving scientific innovation, regulatory flexibility and stakeholder engagement 27

vulgaris Beijerinck on 92 patients with major depression

This includes regulatory T (Treg) cells, myeloid-derived suppressor cells, tumor-associated macrophages, and increased expression of various immunosuppressive molecules, such as PD-1 and PD-L1

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease