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The patients who report the strongest response are those who are already active, eat well, and are looking to optimize cellular energy output rather than compensate for lifestyle gaps
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When patients learn (sometimes the hard way) that using opioids will not give the high they are looking for and can cause 10/10 withdrawal sickness, its clearly not worth the relapse
It works through a different mechanism (fat oxidation via beta-3 adrenergic receptors, not appetite suppression), and that mechanism produces gradual, subtle changes
As an analogy and a proof of concept, this fully substantiated the particularities of therapy outcomes in schizophrenia-like models [171,200]
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