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[PubMed: 12745277] 184

L.SheetsH

Activation of proteases by extracellular acidosis that degrade connective tissues increases access to neural and vascular K + to enhance migration and metastasis

This duration balances therapeutic benefits with manageable treatment commitment and cost considerations

The studies in yeast provided the first direct evidence for ATP-dependent, low-affinity transport of GSH in any cell type (Rebbeor et al., 1998a), and demonstrated that this ATP-dependent GSH transport in yeast is mediated by Ycf1p, the yeast orthologue of mammalian MRP1 and MRP2 (Rebbeor et al., 1998b)

Study Duration: Between 20 to 52 weeks