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Glutamate and microglia activation as a driver of dendritic apoptosis: A core pathophysiological mechanism to understand schizophrenia

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The D1-like family, including D 1 receptors (D 1 Rs) and D 5 receptors (D 5 Rs), is associated with stimulatory G proteins (Gs), whereas the D2-like family, including D 2 receptors (D 2 Rs), D 3 receptors (D 3 Rs), and D 4 receptors (D 4 Rs), is linked to inhibitory G proteins (Gi and Go)

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A double-blind, placebo-controlled study evaluating the effects of caffeine and l-theanine both alone and in combination on cerebral blood flow, cognition and mood

thus, the phenotype is manifest fully in males whereas female heterozygotes display varying degrees of G6PD deficiency, due to alternate X-chromosome inactivation 3,4