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Proliferation and growth of several types of cancer cells are inhibited by MR, while normal cells are unaffected by limiting methionine as long as homocysteine is present [9]

Reduction of cGMP levels in neuronal cells is reported to alleviate neuropathic pain in spared injury model in rats 55

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The commonly used time points for different species are as follows: rodents, 2 or 4 weeks