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doi: 10.3892/ol.2019.9888 234 YuanYCaoWZhouHQianHWangH

The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

IV therapy ensures full bioavailability, offering superior results compared to the effects of injections or oral supplementation

Recently, a dose-dependent increase in cerebrospinal fluid (CSF) total and reduced NAC concentrations was demonstrated in association with oral NAC administration

EFS rate, 31%) than patients with a low-disease burden (12-month OS rate, 85%

[DOI] [PMC free article] [PubMed] [Google Scholar] Choy C.A., Popp B.N., Kaneko J.J., Drazen J.C