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A case report and literature review

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Four patients (~20%) had a reduced frequency of cytotoxic CD56 dim NK cells together with an altered BM NK transcriptome that featured enriched expression of genes encoding enrichment of inhibitory receptors ( KLRB1 and KLRC1 ) and decreased expression of genes encoding activating receptors such as FCGR3A (CD16), NCR3 (NKp30), and CD226 (DNAM1)

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