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unilateral or bilateral
Tables 1 and 2 summarize passive membrane diffusion and active transport membrane permeability, respectively, for select small molecule NNMT inhibitors for which structure activity relationships had been previously developed.[17] 1-MNA, a product inhibitor of NNMT[12, 24, 25] exhibited no passive permeability (Table 1)

Treatment duration at this dose typically ranges from 8-12 weeks, followed by an appropriate off-cycle period

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