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Barrier function, tissue integrity, immune signaling, and the gut's broader relationship with systemic physiology are all deeply interconnected - which means the most meaningful research questions tend to involve multiple systems at once
Instead, they are biogenetically related to lignans and neolignans, sharing similar biosynthetic pathways, and are derived from two phenylpropanoid units with an additional structure that classifies them under flavonoids [572]
J.FinkJ
ESPEN 51, 207214
doi: 10.1073/pnas.1720017115 108
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