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Melatonin synthesized in the pineal gland is rapidly and pulsatilely released into the bloodstream and cerebrospinal fluid, from where it is distributed to organs and tissues throughout the body. MELATONIN RECEPTORS Activation of melatonin receptors determines the subsequent biological effects

Theories of depressive disorders include the monoaminergic, neurotrophic, glucocorticosteroid, glutaminergic, inflammatory, and cytokine theories

Gastroprotective signaling pathway activity

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