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In human populations, selenium deficiency, due to lack of selenium in the soil, has been found to cause Keshan disease (6, 138, 216, 305), a cardiomyopathy, and Kashin-Beck disease (287, 393), an osteoarthropathy, in part, due to reductions in GPx-1 expression

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To block the JNK/c-Jun cascade, the keratinocytes were subsequently exposed to 10 M SP600125 (HY-12041, MedChemExpress) for 12 h following M5 stimulation

In 1987, a young visitor from Sweden, Jan Alberts, came to my lab