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IGF-1 binds mainly to IGF-1 receptors located in the skeletal muscle and/or hybrid insulin/IGF-1 receptors, and it has been postulated as the mediator of enhanced insulin action as it binds insulin receptors with very low affinity (179)

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Additionally, the antioxidant enzyme activities of GP and superoxide dismutase were reported to be dysregulated in red blood cells and serum of obese individuals compared to controls (27, 28)

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First, since this is a narrative review rather than a systematic review, the selection of studies evaluated in this review may have introduced biases due to the limited availability of research articles on certain aspects of the topic