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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

Yadav A, Schmitt S, Ma W, Mobley JA, Thalacker-Mercer AE

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Abdel-Razzak Z, Garlatti M, Aggerbeck M, Barouki R

Min JY, Min KB (2016) Blood cadmium levels and Alzheimers disease mortality risk in older US adults

Always inform your GP and pharmacist about all supplements and over-the-counter products you are taking