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10.1016/j.regpep.2012.12.007 9 BecejacT.CesarecV.DrmicD.HirslD.MadzaracG.DjakovicZ.et al (2018)

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Abbreviations SIRT1, Sirtuin 1

Glutaminase inhibitors, such as CB-839, have shown promise in preclinical studies and early-phase clinical trials, demonstrating their ability to impede glutamine catabolism and disrupt the supply of glutamate, a precursor for numerous biosynthetic pathways critical for cancer cell survival and proliferation [12,55]

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