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Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

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Its half maximal inhibitory concentration (IC50) for NE is 0.7 nM, significantly lower than brensocatibs 4.0 nM, indicating enhanced inhibitory activity

Different forms of supplementation are available, including oral capsules (400-1000 mcg per day), sublingual B12 (1000-5000 mcg per day), and injections (5000 mcg weekly)