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Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, et al

AbbVie reported that ABBV-295 demonstrated clinically meaningful body weight reduction ranging from approximately 7.75% to 9.79% over the treatment period, while also showing a favorable tolerability profile with no serious adverse events reported

[2] Your GP may: Refer you to psychological services if anxiety symptoms are significant, including NHS Talking Therapies for anxiety and depression Consider whether anxiety treatment should be optimised before or alongside GLP-1 therapy, following NICE guidance for anxiety disorders Coordinate care with diabetes specialists, dietitians, and mental health professionals Review the risk-benefit balance of continuing GLP-1 treatment if mental health concerns arise Screen for and manage eating disorders according to NICE guidance before initiating or continuing weight-loss treatments Remember that GLP-1 medications are not a treatment for anxiety, and any mental health benefits are likely secondary to metabolic improvements

CagriSema has the stronger evidence base with completed phase 3 REDEFINE trials showing 20.4% weight loss, and is closer to potential approval

In the body, GLP-1 acts as a multifunctional hormone with three main effects: Central appetite regulation: GLP-1 receptors in the brains appetite centres signal satiety, helping individuals feel full sooner and reducing cravings

Phenolic compounds have long been known to possess biological functions