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Our findings suggest that BDFs anticonstipation effects are dose-dependent, with high doses significantly improving outcomes, including fecal count, water content, and propulsion rate

doi: 10.1021/bi300752r

doi: 10.1038/nri.2017.1 321 WangDLinWPanYKuangXQiXSunH

All four candidates were classified as BBB-penetrating by the final model

While currently no structure of SmTGRTrx complex exists, when aligning the available crystal structure of plasmodium TrxRTrx (PDB 4J56) with SmTGR one can infer where Trx (shown in orange) binds to SmTGR (Figure 1)

(2021) 184:44644479.e19
