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doi: 10.1016/j.tplants.2020.02.002 76 WachterA.WolfS.SteiningerH.BogsJ.RauschT

The cleaner independent support is a 2021 study in APP/PS1 Alzheimer's-model mice (Sun 2021, PMID 34827486), which reported improved Morris water maze performance and increased synaptophysin via PI3K/AKT

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331 This shift in HIF expression likely underlies the observation that under conditions of prolonged hypoxia the initial protective mechanisms of the kidney either fail to be engaged or are down-regulated

La combinacin adecuada de experimentos in vivo e in vitro revelar si las sustancias qumicas son nefrotxicas o no y dar idea de la potencia, la localizacin y los mecanismos de la toxicidad