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Clinical Outcomes of HCV-Related Renal Disease A retrospective cohort study involving more than 470,000 adult veterans showed that persons with chronic HCV infection were more likely to develop end-stage renal disease (4.3 per 1,000 person-years) than HCV-seronegative patients (3.1 per 1,000 person-years).[13] A subsequent cross-sectional study showed that persons with HCV infection had a 40% higher likelihood of developing renal insufficiencydefined as serum creatinine levels greater than or equal to 1.5 mg/dLcompared with seronegative participants.[11] Treatment of HCV in Renal Disease One multicenter observational study of 139 patients with kidney disease from mixed cryoglobulinemia suggested that DAA treatment was associated with reduced mortality and improved kidney survival in that cohort.[56] Successful clearance of HCV with DAA therapy is associated with improved clinical outcomes, including reduced risk of chronic kidney disease and a survival benefit in patients on dialysis.[57,58] The treatment of HCV in persons with renal disease is addressed in detail in this curriculum in the topic review Treatment of HCV in Persons with Renal Impairment

While cutaneous melanocytic nevi frequently exhibit somatic, activating mutations in the BRAF or NRAS oncogenes, it remains unclear if similar mutations are also implicated in the pathogenesis of oral mucosal nevi