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Further investigation into the testicular microenvironment using a co-culture system of senescent TM3 Leydig cells and GC-1 spg spermatogonia revealed that H2O2-induced senescent TM3 cells secreted increased levels of SASP factors, particularly IL-6 and TGF-

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These drugs specifically bind to opioid receptors in the brain, producing a sensation of euphoria and relaxation while curbing pain

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This heightened activity overloads the electron transport chain, causing electron leakage and excessive ROS generation

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