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166 Moreover, oridonin, a tetracyclic diterpenoid extracted from Rabdosia labtea , induced markers associated with apoptosis in gemcitabine-resistant PANC-1 pancreatic cancer cells, while concurrently inhibiting the expression of GSTP1

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Ni T, Huang X, Pan S, Lu Z

R.AdewuyiO.et al

Strains carrying an HA-tagged version of Adh2 were generated by similar approaches using pYM-N16 (EG103 pGPD-3HA-ADH2 and EG110 pGPD-3HA-ADH2 ) or pYM-N14 (EG103 ADH2-6HA and EG110 ADH2-6HA ) as templates and primers ADH2_S1 and ADH2_S4 or 5-GGCATACTTGATAATGAAAACTATAAATCGTAAAGACATAAGAGATCCGCTTAATCGATGAATTCGAGCTCG-3 (ADH2_S2) and 5-AGATGGAGAAGGGCCAAATTGCTGGTAGATACGTTGTTGACACTTCTAAACGTACGCTGCAGGTCGAC-3(ADH2_S3), respectively

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, suppresses glycolysis and thereby exhibits an anti-proliferative effect on ATC cells [76]

However, we consider that there are still multiple areas of opportunity to improve their health status and increase their quality of life