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Constipation ranks among the top three complaints from GLP-1 medication users, affecting up to 24% of patients in clinical trials

The BBB represents a major challenge

Note that the cases used are hypothetical and created solely to illustrate core concepts

Choice of study modality varies greatly based on patient presentation and risk factors

KEYWORDS: tirzepatide, colonic ischemia, glucagon-like peptide-1 receptor agonists INTRODUCTION Colonic ischemia (CI) is the most common form of gastrointestinal ischemic disease and most commonly presents with abrupt onset of abdominal pain followed by bloody diarrhea

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