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Following recognition, the substrate is deubiquitinated, unfolded, and eventually broken down by the proteasome

and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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Innovations in analytical methods and therapeutic strategies Advances in analytic methods Advancements in detection technologies have greatly enhanced our understanding of liver repair and regeneration

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This is due in part to GSTs ability to fold quickly into a soluble protein upon translation